The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studiesReportar como inadecuado

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International Journal of Bipolar Disorders

, 5:1

First Online: 20 January 2017Received: 09 September 2016Accepted: 04 January 2017


BackgroundPrevious studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence’s and levels of antithyroid peroxidase antibodies TPO-Abs in offspring and co-twins without a mood disorder compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor trait marker for BD development.

ObjectivesHere we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a ‘trait’ marker for BD. The present study aims to investigate whether TPO-Abs 1 are stable over time, 2 are associated with lithium-exposure, 3 share a common genetic background with BD and are related to psychopathology.

ResultsIn bipolar offspring and twins, the prevalence of TPO-Abs is stable over time rs = .72 p < .001 resp. rs = .82, p < .001 and not associated with lithium use. At follow-up, an increased prevalence of TPO-abs was again observed in bipolar offspring 10,4% versus 4% and higher TPO-abs titers were still present in co-twins of bipolar cases compared to control twins mean 1.06 IU-ml SD .82 versus mean .82 IU-ml SD .67, although statistical significance was lost.

ConclusionsAlthough our results show a trend toward an increased inherited risk of the co-occurrence of BD and thyroid autoimmunity, large-scale studies can only draw final conclusions. Nationwide epidemiological and GWAS studies reach such numbers and support the view of a possible common autoimmune etiology of severe mood disorders and chronic recurrent infections and autoimmunity, including thyroid autoimmunity.

KeywordsThyroid peroxidase antibodies Bipolar disorder Offspring Twins Prevalence AbbreviationsTPO-Absantithyroid peroxidase antibodies

AITDautoimmune thyroiditis

BDbipolar disorder


DBODutch bipolar offspring

FH-RDCfamily history research diagnostic criteria

IRRincidence rate ratio


MDmood disorders


SCID-IStructured Clinical Interview for DSM-IV

SDstandard deviation

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Autor: G. Snijders - L. de Witte - E. Mesman - S. Kemner - R. Vonk - R. Brouwer - W. A. Nolen - H. A. Drexhage - M. H. J. H


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