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Journal of Neural Transmission

pp 1–9

First Online: 27 June 2017Received: 10 February 2017Accepted: 09 June 2017

Abstract

Alterations in monoaminergic signaling are suggested as key aspects of the pathophysiology in bipolar disorder and ADHD, but it is not known if the monoamine metabolic profile differs between these disorders. One method to study monoaminergic systems in humans is to measure monoamine end-point metabolite concentrations in cerebrospinal fluid CSF. Here, we analyzed CSF monoamine metabolite concentrations in 103 adults with bipolar disorder, 72 adults with ADHD, and 113 controls. Individuals with bipolar disorder had significantly higher homovanillic acid HVA, 264 ± 112 nmol-L, p < 0.001 and 5-hydroxyindoleacetic acid 5-HIAA, 116 ± 42 nmol-L, p = 0.001 concentration, but lower 3-methoxy-4-hydroxyphenylethyleneglycol MHPG, 38 ± 8 nmol-L, p < 0.001 concentrations than controls HVA, 206 ± 70 nmol-L; 5-HIAA, 98 ± 31 nmol-L; and MHPG, 42 ± 7 nmol-L. Higher HVA concentrations were associated with a history of psychosis in the bipolar disorder sample. Subjects with ADHD had higher HVA 240 ± 94 nmol-L, p < 0.001 concentrations compared with controls. In addition, SSRI treatment was associated with lower 5-HIAA concentrations in both patient groups. A power analysis indicated that for within-group comparisons, only large effects would be reliably detectable. Thus, there may be moderate-to-small effects caused by medication that were not detected due to the limited size of the sub-groups in these analyses. In conclusion, the present study suggests disorder-specific alterations of CSF monoamine metabolite concentrations in patients with bipolar disorder and ADHD compared with controls; these differences were independent of acute symptoms and medication effects.

KeywordsBipolar disorder ADHD Cerebrospinal fluid Dopamine Serotonin Norepinephrine Monoamines  Download fulltext PDF



Autor: Erik Pålsson - Carl Sellgren - Eleonore Rydén - Ruth Kizza - Aurimantas Pelanis - Henrik Zetterberg - Kaj Blennow - Mikae

Fuente: https://link.springer.com/







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