Novel 5,6-Dihydropyrrolo2,1-aisoquinolines as Scaffolds for Synthesis of Lamellarin AnaloguesReportar como inadecuado

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Evidence-Based Complementary and Alternative MedicineVolume 2011 2011, Article ID 103425, 6 pages

Research Article

College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China

Liaoning Key Laboratory of Bio-Organic Chemistry, Dalian University, Dalian 116622, China

College of Agronomy, Northwest A&F University, Yangling 712100, China

Received 31 December 2010; Accepted 3 June 2011

Copyright © 2011 Shao Han Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As core skeletons of lamellarins: 5,6-Dihydropyrrolo2,1-aisoquinolines are one of the important alkaloids that exhibit significant biological activities, in this study, an efficient synthetic route was described for two novel compounds, 5,6-dihydropyrrolo2,1-aisoquinolines I and II. Compound I was synthesized from isovanillin with 28.3% overall yield by a six-step reaction while II from 2-3,4-dimethoxyphenyl ethanamine was with 61.6% overall yield by a three-step reaction. And the structures of these two compounds were confirmed by means of IR spectrum,


C NMR, MS, HRMS, and melting point measurements.

Autor: Shao Han Liao, Dai Hua Hu, Ai Ling Wang, and De Peng Li



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