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Evidence-Based Complementary and Alternative Medicine - Volume 2015 2015, Article ID 103416, 8 pages -

Research Article

Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh

Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh

Department of Pharmacy, University of Asia Pacific, Dhaka 1209, Bangladesh

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh

Received 29 April 2015; Revised 30 July 2015; Accepted 2 August 2015

Academic Editor: Angelo A. Izzo

Copyright © 2015 Sara Tasnim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Studies have shown that Allium sativum L. AS protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer’s disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A AS and B placebo. Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery CANTAB twice: at the beginning and after five weeks of the study. We found statistically significant difference in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS.





Autor: Sara Tasnim, Parsa Sanjana Haque, Md. Sazzadul Bari, Md. Monir Hossain, Sardar Mohd. Ashraful Islam, Mohammad Shahriar, Mohi

Fuente: https://www.hindawi.com/



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