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Mediators of Inflammation - Volume 4 1995, Issue 5, Pages 339-343



Leiden-Amsterdam Center for Drug Research, Division of Molecular Pharmacology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, Amsterdam 1081 HV, The Netherlands

Leiden-Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, Amsterdam 1081 HV, The Netherlands

N.V. Organon, Department of Drug Metabolism and Kinetics, P.O. Box 20, Oss 5340 BH, The Netherlands



Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

During inflammation an influx of neutrophils and release of mediators from mast cells such as histamine take place. The stimulated neutrophils can produce reactive oxygen species ROS. One of these ROS is the highly reactive hydroxyl radical OH

. It would be interesting to be able to quantify the extent of ROS formation. We investigated if histamine which is present at the inflammation site can serve as an endogenous marker for the formation of OH

. We found that histamine after incubation with OH

gave two distinct products in our HPLC system. One of the products gave the same characteristics as the synthesized 2-imidazolone derivative of histamine. This suggests that this derivative will be formed when histamine is incubated with OH

.





Autor: T.-L. Ching, R. M. van der Hee, N. M. Bhoelan, J. Blauw, W. M. P. B. Menge, J. de Jong, and A. Bast

Fuente: https://www.hindawi.com/



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