Plasma Aminothiol Profile and Some of Its Determinants in Apparently Healthy Azorean SubjectsReportar como inadecuado

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ISRN Oxidative Medicine - Volume 2014 2014, Article ID 961013, 9 pages -

Research ArticleCenter of Research in Natural Resources CIRN and Department of Technological Sciences and Development, University of the Azores, Ponta Delgada, 9501-801 Azores, Portugal

Received 22 October 2013; Accepted 6 January 2014; Published 16 February 2014

Academic Editors: P. Leroy and N. Visavadiya

Copyright © 2014 Ana Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To evaluate the plasma aminothiol profile PAP and serum gamma-glutamyltransferase GGT activity, as well as plasma folate, vitamin B12, and vitamin B6 concentrations, in 326 apparently healthy subjects from the Azores archipelago Portugal. Also eventual relationships of PAP with conventional risk factors for atherosclerosis were investigated, aiming at the finding of early blood markers of the disease. Design and Methods. This was an observational cross-sectional study, where participants were split into two groups: one with a normal and another with an altered PAP at least one aminothiol out of its reference concentration range. Results. About 76% of subjects had an altered PAP, mainly due to low glutathione levels <1.5 μmol-L, mostly associated with normal GGT activity. Prevalence of hyperhomocysteinemia was 10%, where only 33% had some B-vitamin deficiency. The risk for atherosclerosis was more evidenced in subjects exhibiting both deficient GSH concentration and increased serum GGT activity. Conclusions. An altered PAP, namely, when caused by low GSH levels in the absence of alterations in the Hcy, or Cys, or Cys-Gly concentrations and in serum GGT activity, might reveal a subclinical stage of atherogenesis and should be explored as a potential early marker of atherosclerosis.

Autor: Ana Lima, Rita Ferin, José Baptista, and M. Leonor Pavão



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