Differential immunotoxicity of histone deacetylase inhibitors on malignant and naïve hepatocytesReportar como inadecuado




Differential immunotoxicity of histone deacetylase inhibitors on malignant and naïve hepatocytes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

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Abstract : Histone deacetylases HD represent a novel target in cancer treatment, in particular of scattered small tumours such as the hepatocellular carcinoma HCC. However, only few studies address the toxicological impact of HD Inhibitors HDIs on malignantly transformed cells versus primary hepatocytes. We examined whether and how different classes of HDIs sensitise the human HCC cell line HepG2, primary healthy murine and human liver cells towards the death receptor agonists TNFα and CD95L.

Keywords : ActD CBHA HDAC HDI M344 VPA TNF TRAIL CD95L cFLIP XIAP Hepatocellular carcinoma Adverse side effect Primary hepatocytes





Autor: Markus Weiller Timo Weilandl Georg Dünstl Ulrike Sack Gerald Künstle Albrecht Wendel -

Fuente: https://hal.archives-ouvertes.fr/



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