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Arthritis Research and Therapy

, 3:118

First Online: 05 January 2001Received: 23 August 2000Revised: 22 November 2000Accepted: 04 December 2000

Abstract

Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.

Keywordschemokine monocyte rheumatoid arthritis AbbreviationsELISA= enzyme-linked immunosorbent assay

IP-10= interferon-gamma inducible protein 10

mAb= monoclonal antibody

MCP-1= monocytechemotactic protein-1

MIP= macrophage inflammatory protein

OA= osteoarthritis

PBMC= peripheral blood mononuclear cells

PE= phycoerythrin

RA= rheumatoid arthritis

RANTES= regulated upon activation normal T cell expressed and secreted

RT-PCR= reverse transcriptase-polymerasechain reaction

SCL= stromal cell line

SRBC= sheep red blood cells

TNF-α= tumor necrosis factor-α.

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Autor: Kenji Hayashida - Toshihiro Nanki - Hermann Girschick - Sule Yavuz - Takahiro Ochi - Peter E Lipsky

Fuente: https://link.springer.com/







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