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Journal of Chemistry - Volume 2014 2014, Article ID 317536, 9 pages -

Review Article

1st Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, 154 Mesogion Street, 11527 Athens, Greece

1st Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, 75 Micras Asias, Goudi, 11527 Athens, Greece

Laboratory of Biochemistry, Faculty of Chemistry, National & Kapodistrian University of Athens, 75 Micras Asias, Goudi, 11527 Athens, Greece

Received 13 March 2014; Accepted 8 June 2014; Published 2 July 2014

Academic Editor: Alexander Govaris

Copyright © 2014 Marilita M. Moschos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Age-related macular degeneration ARMD is the leading cause of severe vision loss and blindness worldwide, mainly affecting people over 65 years old. Dry and wet ARDM are the main types of the disease, which seem to have a multifactorial background. The aim of this review is to summarize the mechanisms of ARMD pathogenesis and exhibit the role of diet and nutritional supplements in the onset and progression of the disease. Environmental factors, such as smoking, alcohol, and, diet appear to interact with mutations in nuclear and mitochondrial DNA, contributing to the pathogenesis of ARMD. Inflammatory mediators and oxidative stress, induced by the daily exposure of retina to high pressure of oxygen and light radiation, have been also associated with ARMD lesions. Other than medical and surgical therapies, nutritional supplements hold a significant role in the prevention and treatment of ARMD, eliminating the progression of macular degeneration.





Autor: Marilita M. Moschos, Eirini Nitoda, Irini P. Chatziralli, and Constantinos A. Demopoulos

Fuente: https://www.hindawi.com/



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