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Case Reports in Oncological Medicine - Volume 2015 2015, Article ID 317493, 5 pages -

Case Report

Department of Pathology, Duke University, DUMC Box 3712, Durham, NC 27710, USA

St. George’s University, St. George, Grenada

Department of Surgery, Duke University, 3116 North Duke Street, Durham, NC 27704, USA

Department of Medicine, Duke University, DUMC Box 3198, Durham, NC 27710, USA

Received 22 July 2014; Accepted 14 December 2014

Academic Editor: Cesar V. Reyes

Copyright © 2015 Xiaoyin Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rhabdomyosarcomatous dedifferentiation of GIST following tyrosine kinase inhibitor TKI therapy is rare, with only a handful of cases previously reported in the literature. Herein we present a case of metastatic GIST initially treated with imatinib that developed radiographic evidence of progression after 8 months of standard dose therapy with continued progression despite attempts at using dose-escalated imatinib 400 mg bid. Due to the patient’s worsening clinical symptoms and radiographic concerns for colonic thickening, abscess, and extraluminal air, the patient underwent a palliative resection of a large heterogeneous mass arising from the posterior stomach and several metastatic foci. Pathology revealed a dedifferentiated GIST with rhabdomyosarcomatous features. This report will highlight the unique features of this case and review the existing literature.





Autor: Xiaoyin Jiang, H. Bryan Anderson, Cynthia D. Guy, Paul J. Mosca, Richard F. Riedel, and Diana M. Cardona

Fuente: https://www.hindawi.com/



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