To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud’s phenomenon in South Korea; Korean Raynaud study KOARA studyReportar como inadecuado




To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud’s phenomenon in South Korea; Korean Raynaud study KOARA study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Clinical Rheumatology

, 28:553

First Online: 22 January 2009Received: 18 March 2008Revised: 24 December 2008Accepted: 27 December 2008

Abstract

This study examined the efficacy and safety of nifedipine sustained release nifedipine SR compared with Ginkgo biloba extract as treatment for primary Raynaud’s phenomenon RP in Korea. Primary RP were screened and assigned to either the nifedipine SR group Group N or the Ginkgo biloba extract group Group G in the ratio of 2:1. After a run-in period of 2 weeks, patients received treatment for 8 weeks. We observed the percent improvement of the RP attack rate between before and after the 8-week treatment. Ninety-three subjects were randomly assigned. The percent improvement in Group N was 50.1% at 8 weeks after treatment, while it was 31.0% in Group G p = 0.03. No serious adverse events occurred, and almost adverse events were mild and improved without specific treatment. nifedipine SR was more effective than Ginkgo biloba extract for treatment of primary RP in Korean patients. Both drugs were tolerable with primary RP patients.

KeywordsGinkgo Ginkgo biloba extract Nifedipine Nifedipine sustained release Primary Raynaud’s phenomenon Raynaud’s phenomenon  Download fulltext PDF



Autor: Whan-Seok Choi - Chang-Jin Choi - Kyung-Soo Kim - Jae-Ho Lee - Chan-Hee Song - Ju-Hye Chung - Sun-Myeoung Ock - Jung-Bok L

Fuente: https://link.springer.com/







Documentos relacionados