Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer.Reportar como inadecuado




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* Corresponding author 1 Institut d-oncologie-développement Albert Bonniot de Grenoble 2 Laboratoire recherche et développement 3 Département Pluridisciplinaire de Médecine, Dermatologie 4 Département d-anatomie et cythologie pathologique 5 INSERM U823, équipe 9 Immunobiologie et Immunothérapie des Cancers Institut d-oncologie-développement Albert Bonniot de Grenoble, Laboratoire recherche et développement 6 INSERM U823, équipe 7 Voies Oncogéniques Des Hémopathies Malignes Institut d-oncologie-développement Albert Bonniot de Grenoble, Département de cancérologie et d-hématologie 7 Laboratoire d-Immunocytologie 8 Unité Mixte de Thérapie Cellulaire et Tissulaire

Abstract : Dendritic cells DC, considered as immunological sentinels of the organism since they are antigen presenting cells, create the link between innate and adaptive immunity. DC include myeloid dendritic cells MDC and plasmacytoid dendritic cells PDC. The presence of PDC, cells capable of producing large quantities of interferon alpha IFN-alpha in response to pathogenic agents or danger signals, seems to be closely related to pathological conditions. PDC have been observed in inflammatory immunoallergic dermatological disorders, in malignant cutaneous tumours and in cutaneous lesions of infectious origin. They seem to play a crucial role in the initiation of the pathological processes of autoimmune diseases such as lupus or psoriasis. Their function within a tumour context is not as well known and is controversial. They could have a tolerogenic role towards tumour cells in the absence of an activator but they also have the capacity to become activated in response to Toll-like receptor TLR ligands and could therefore be useful for therapeutic purposes.





Autor: Julie Charles - Laurence Chaperot - Dimitri Salameire - Jérémy Di Domizio - Caroline Aspord - Rémy Gressin - Marie-Christine J

Fuente: https://hal.archives-ouvertes.fr/



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