Lateralization of functional magnetic resonance imaging fMRI activation in the auditory pathway of patients with lateralized tinnitusReportar como inadecuado




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Neuroradiology

, Volume 49, Issue 8, pp 669–679

First Online: 03 April 2007Received: 15 November 2006Accepted: 27 February 2007

Abstract

IntroductionTinnitus is hypothesized to be an auditory phantom phenomenon resulting from spontaneous neuronal activity somewhere along the auditory pathway. We performed fMRI of the entire auditory pathway, including the inferior colliculus IC, the medial geniculate body MGB and the auditory cortex AC, in 42 patients with tinnitus and 10 healthy volunteers to assess lateralization of fMRI activation.

MethodsSubjects were scanned on a 3T MRI scanner. A T2*-weighted EPI silent gap sequence was used during the stimulation paradigm, which consisted of a blocked design of 12 epochs in which music presented binaurally through headphones, which was switched on and off for periods of 50 s. Using SPM2 software, single subject and group statistical parametric maps were calculated. Lateralization of activation was assessed qualitatively and quantitatively.

ResultsTinnitus was lateralized in 35 patients 83%, 13 right-sided and 22 left-sided. Significant signal change Pcorrected < 0.05 was found bilaterally in the primary and secondary AC, the IC and the MGB. Signal change was symmetrical in patients with bilateral tinnitus. In patients with lateralized tinnitus, fMRI activation was lateralized towards the side of perceived tinnitus in the primary AC and IC in patients with right-sided tinnitus, and in the MGB in patients with left-sided tinnitus. In healthy volunteers, activation in the primary AC was left-lateralized.

ConclusionOur paradigm adequately visualized the auditory pathways in tinnitus patients. In lateralized tinnitus fMRI activation was also lateralized, supporting the hypothesis that tinnitus is an auditory phantom phenomenon.

KeywordsMagnetic resonance imaging Tinnitus Auditory pathways Inferior colliculus Auditory diseases, central  Download fulltext PDF



Autor: Marion Smits - Silvia Kovacs - Dirk de Ridder - Ronald R. Peeters - Paul van Hecke - Stefan Sunaert

Fuente: https://link.springer.com/







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