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BMC Hematology

, 8:2

First Online: 26 June 2008Received: 14 May 2008Accepted: 26 June 2008

Abstract

BackgroundAlthough it is widely appreciated that vigorous physical activity can increase the risk of bleeding episodes in children with haemophilia, the magnitude of the increase in risk is not known. Accurate risk estimates could inform decisions made by children with haemophilia and their parents about participation in physical activity and aid the development of optimal prophylactic schedules. The aim of this study is to provide an accurate estimate of the risks of bleeding associated with vigorous physical activity in children with haemophilia.

Methods-DesignThe study will be a case-crossover study nested within a prospective cohort study. Children with moderate or severe haemophilia A or B, recruited from two paediatric haematology departments in Australia, will participate in the study. The child, or the child-s parent or guardian, will report bleeding episodes experienced over a 12-month period. Following a bleeding episode, the participant will be interviewed by telephone about exposures to physical activity in the case period 8 hours before the bleed and 2 control periods an 8 hour period at the same time on the day preceding the bleed and an 8 hour period two days preceding the bleed. Conditional logistic regression will be used to estimate the risk of participating in vigorous physical activity from measures of exposure to physical activity in the case and control periods.

DiscussionThis case-control study will provide estimates of the risk of participation in vigorous physical activity in children with haemophilia.

AbbreviationsSMSshort messaging service

Haemophilia AFactor VIII deficiency

Haemophilia BFactor IX deficiency

BMIBody Mass Index

MAQModifiable Activity Questionnaire

METMetabolic Equivalents.

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Autor: Carolyn R Broderick - Robert D Herbert - Jane Latimer - Chris Barnes - Julie A Curtin - Paul Monagle

Fuente: https://link.springer.com/article/10.1186/1471-2326-8-2



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