Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: a feasibility trialReportar como inadecuado




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Arthritis Research and Therapy

, 12:R25

First Online: 12 February 2010Received: 14 September 2009Revised: 10 December 2009Accepted: 12 February 2010

Abstract

IntroductionManagement of osteoarthritis OA includes the use of non-pharmacological and pharmacological therapies. Although walking is commonly recommended for reducing pain and increasing physical function in people with OA, glucosamine sulphate has also been used to alleviate pain and slow the progression of OA. This study evaluated the effects of a progressive walking program and glucosamine sulphate intake on OA symptoms and physical activity participation in people with mild to moderate hip or knee OA.

MethodsThirty-six low active participants aged 42 to 73 years were provided with 1500 mg glucosamine sulphate per day for 6 weeks, after which they began a 12-week progressive walking program, while continuing to take glucosamine. They were randomized to walk 3 or 5 days per week and given a pedometer to monitor step counts. For both groups, step level of walking was gradually increased to 3000 steps-day during the first 6 weeks of walking, and to 6000 steps-day for the next 6 weeks. Primary outcomes included physical activity levels, physical function self-paced step test, and the WOMAC Osteoarthritis Index for pain, stiffness and physical function. Assessments were conducted at baseline and at 6-, 12-, 18-, and 24-week follow-ups. The Mann Whitney Test was used to examine differences in outcome measures between groups at each assessment, and the Wilcoxon Signed Ranks Test was used to examine differences in outcome measures between assessments.

ResultsDuring the first 6 weeks of the study glucosamine supplementation only, physical activity levels, physical function, and total WOMAC scores improved P < 0.05. Between the start of the walking program Week 6 and the final follow-up Week 24, further improvements were seen in these outcomes P < 0.05 although most improvements were seen between Weeks 6 and 12. No significant differences were found between walking groups.

ConclusionsIn people with hip or knee OA, walking a minimum of 3000 steps ~30 minutes, at least 3 days-week, in combination with glucosamine sulphate, may reduce OA symptoms. A more robust study with a larger sample is needed to support these preliminary findings.

Trial RegistrationAustralian Clinical Trials Registry ACTRN012607000159459.

AbbreviationsBMIbody mass index

ESeffect size

GSglucosamine sulphate

NSAIDsnonsteroidal anti-inflammatory drugs

OAosteoarthritis

SDstandard deviation

SPSself-paced step test

WOMAC Osteoarthritis IndexWestern Ontario and McMaster Universities Osteoarthritis Index.

Electronic supplementary materialThe online version of this article doi:10.1186-ar2932 contains supplementary material, which is available to authorized users.

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Autor: Norman TM Ng - Kristiann C Heesch - Wendy J Brown

Fuente: https://link.springer.com/



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