Supplementation of diet with krill oil protects against experimental rheumatoid arthritisReportar como inadecuado




Supplementation of diet with krill oil protects against experimental rheumatoid arthritis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Musculoskeletal Disorders

, 11:136

First Online: 29 June 2010Received: 09 March 2010Accepted: 29 June 2010

Abstract

BackgroundAlthough the efficacy of standard fish oil has been the subject of research in arthritis, the effect of krill oil in this disease has yet to be investigated. The objective of the present study was to evaluate a standardised preparation of krill oil and fish oil in an animal model for arthritis.

MethodsCollagen-induced arthritis susceptible DBA-1 mice were provided ad libitum access to a control diet or diets supplemented with either krill oil or fish oil throughout the study. There were 14 mice in each of the 3 treatment groups. The level of EPA + DHA was 0.44 g-100 g in the krill oil diet and 0.47 g-100 g in the fish oil diet. Severity of arthritis was determined using a clinical scoring system. Arthritis joints were analysed by histopathology and graded. Serum samples were obtained at the end of the study and the levels of IL-1α, IL-1β, IL-7, IL-10, IL-12p70, IL-13, IL-15, IL-17 and TGF-β were determined by a Luminex™ assay system.

ResultsConsumption of krill oil and supplemented diet significantly reduced the arthritis scores and hind paw swelling when compared to a control diet not supplemented with EPA and DHA. However, the arthritis score during the late phase of the study was only significantly reduced after krill oil administration. Furthermore, mice fed the krill oil diet demonstrated lower infiltration of inflammatory cells into the joint and synovial layer hyperplasia, when compared to control. Inclusion of fish oil and krill oil in the diets led to a significant reduction in hyperplasia and total histology score. Krill oil did not modulate the levels of serum cytokines whereas consumption of fish oil increased the levels of IL-1α and IL-13.

ConclusionsThe study suggests that krill oil may be a useful intervention strategy against the clinical and histopathological signs of inflammatory arthritis.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-11-136 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Michelle Ierna - Alison Kerr - Hannah Scales - Kjetil Berge - Mikko Griinari

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados