Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trialReportar como inadecuado




Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Arthritis Research and Therapy

, 12:R126

First Online: 01 July 2010Received: 18 March 2010Revised: 03 June 2010Accepted: 01 July 2010

Abstract

IntroductionThe microdialysis method was applied to the human knee joint with osteoarthritis OA in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading.

MethodsThirty-one female subjects with OA of the knee were randomized to non-exercise NEx or exercise Ex groups. Following acute resistance exercise 25 sets of 10 repetitions at 60% of 1 Repetition Maximum or none NEx, peripheral nerve blocks just below the inguinal ligament were applied and two microdialysis catheters were positioned in two different compartments, intraarticularly and peri-synovially. The microdialysis catheters were perfused at a slow rate 2 μl-minute with a solution of Ringer-acetate and radioactively labelled glucose allowing for determination of relative recovery RR and calculation of interstitial concentrations of inflammatory and cartilage biomarkers over a three-hour period.

ResultsA significant increase of Interleukin IL -10 was discovered in both positions of the knee in the Ex group over the three hours post exercise, whereas IL-10 remained stationary over time in the NEx group. IL-6 and IL-8 displayed significant increases over time regardless of group and position of the catheter. Cartilage oligomeric matrix protein COMP decreased intraarticularly in the post exercise period in the Ex group compared to the NEx group.

ConclusionsExercise caused an increase in both intraarticular and peri-synovial concentrations of IL-10 in a group of human females with knee OA. This suggests a positive effect of exercise on a chondroprotective anti-inflammatory cytokine response in patients with knee OA and might contribute to explaining the beneficial effect that exercise has on OA.

Trial registrationNCT01090375.

AbbreviationsACRAmerican College of Rheumatology

COMPCartilage Oligomeric Matrix Protein

CTX-IITelopeptide

ExExercise group

GAGglycosaminoglycan

ILInterleukin

K-LKellgren-Lawrence

NExNon Exercise group

OAOsteoarthritis

RMRepetition Maximum

RRRelative Recovery

TNF-αTumor Necrosis Factor α.

Electronic supplementary materialThe online version of this article doi:10.1186-ar3064 contains supplementary material, which is available to authorized users.

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Autor: Ida C Helmark - Ulla R Mikkelsen - Jens Børglum - Anders Rothe - Marie CH Petersen - Ove Andersen - Henning Langberg -

Fuente: https://link.springer.com/







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