Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controReportar como inadecuado




Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, contro - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Musculoskeletal Disorders

, 11:264

First Online: 16 November 2010Received: 16 March 2010Accepted: 16 November 2010

Abstract

BackgroundAlthough intra-articular hyaluronic acid is well established as a treatment for osteoarthritis of the knee, its use in hip osteoarthritis is not based on large randomized controlled trials. There is a need for more rigorously designed studies on hip osteoarthritis treatment as this subject is still very much under debate.

Methods-DesignRandomized, controlled trial with a three-armed, parallel-group design. Approximately 315 patients complying with the inclusion and exclusion criteria will be randomized into one of the following treatment groups: infiltration of the hip joint with hyaluronic acid, with a corticosteroid or with 0.125% bupivacaine.

The following outcome measure instruments will be assessed at baseline, i.e. before the intra-articular injection of one of the study products, and then again at six weeks, 3 and 6 months after the initial injection: Pain 100 mm VAS, Harris Hip Score and HOOS, patient assessment of their clinical status worse, stable or better then at the time of enrollment and intake of pain rescue medication number per week. In addition patients will be asked if they have complications-adverse events. The six-month follow-up period for all patients will begin on the date the first injection is administered.

DiscussionThis randomized, controlled, three-arm study will hopefully provide robust information on two of the intra-articular treatments used in hip osteoarthritis, in comparison to bupivacaine.

Trial registrationNCT01079455

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Autor: Sascha Colen - Michel PJ van den Bekerom - Johan Bellemans - Michiel Mulier

Fuente: https://link.springer.com/







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