Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological studyReportar como inadecuado




Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Musculoskeletal Disorders

, 11:271

Pathophysiology of musculoskeletal disorders

Abstract

BackgroundLong head biceps LHB degeneration, in combination with rotator cuff tears, can be a source of chronic shoulder pain. LHB tenotomy reduces pain and improves joint function although the pathophysiological context is not well understood. Tendon integrity depends on the extracellular matrix ECM, which is regulated by matrix metalloproteinases MMP. It is unclear which of these enzymes contribute to LHB but we chose to study MMP 1, 3, and 9 and hypothesized that one or more of them may be altered in LHB, whether diagnosed preoperatively or intraoperatively. We compared expression of these MMPs in both LHB and healthy tendon samples.

MethodsLHB samples of 116 patients with degenerative rotator cuff tears were harvested during arthroscopic tenotomy. Patients were assigned to 4 groups partial thickness tear, full thickness tear, cuff arthropathy, or control based upon intraoperative findings. Partial and full thickness tears were graded according to Ellman and Bateman-s classifications, respectively. MMP expression was determined by immunohistochemistry.

ResultsMMP 1 and 9 expression was significantly higher in the presence of rotator cuff tears than in controls whereas MMP 3 expression was significantly decreased. MMP 1 and 9 expression was significantly higher in articular-sided than bursal-sided partial thickness tears. No significant association was found between MMP 1 and 9 expression and full thickness tears, and the extent of the cuff tear by Bateman-s classification.

ConclusionIncreased MMP 1 and 9 expression, and decreased MMP 3 expression are found in LHB degeneration. There is a significant association between the size and location of a rotator cuff tear and MMP expression.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-11-271 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Stefan Lakemeier - Soeren A Schwuchow - Christian D Peterlein - Christian Foelsch - Susanne Fuchs-Winkelmann - Eleni Archo

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados