The additive prognostic value of perfusion and functional data assessed by quantitative gated SPECT in womenReport as inadecuate

The additive prognostic value of perfusion and functional data assessed by quantitative gated SPECT in women - Download this document for free, or read online. Document in PDF available to download.

Journal of Nuclear Cardiology

, Volume 16, Issue 1, pp 10–19

First Online: 20 January 2009Received: 21 January 2008Revised: 15 July 2008Accepted: 31 July 2008


BackgroundThe aim of this study was to assess the prognostic value of technetium-99m tetrofosmin gated SPECT imaging in women using quantitative gated single photon emission computed tomography SPECT imaging.

MethodsWe followed 453 consecutive female patients. Average follow-up was 1.33 years max. 2.55. Hard endpoints were cardiac death, acute myocardial infarction, or documented ventricular fibrillation. Event-free survival curves were obtained. Optimal cutoff values for left ventricular LV volumes, LV ejection fraction LVEF, and perfusion data to predict outcome were determined by ROC curve analysis.

ResultsA total of 236 patients had an abnormal study, of whom 27 patients experienced hard events 16 deaths and 47 patients soft events. For hard events summed stress score SSS and LVEF, and for any cardiac event SSS showed independent incremental prognostic value. The survival curves were maximally separated when using cutoff values for SSS of ≥22 and LVEF < 52% P < 0.001, HR 4.61 and P < 0.001 HR 5.24 for SSS and LVEF resp., and SSS ≥ 14 P < 0.001 HR 3.76 for any cardiac event.

ConclusionIn women, perfusion and functional parameters derived from quantitative gated technetium-99m tetrofosmin SPECT imaging can adequately be used for cardiac risk assessment. Using quantitative gated SPECT, female patients with an LVEF < 52% or an SSS ≥ 22 are at increased risk for subsequent hard events. Furthermore, patients with an SSS ≥ 14 are at increased risk for any cardiac events.

KeywordsWomen gated single photon emission computed tomography prognosis  Download fulltext PDF

Author: Yves G. C. J. America - Jeroen J. Bax - Eric Boersma - Marcel Stokkel - Ernst E. van der Wall


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