The association between hip fracture and hip osteoarthritis: A case-control studyReportar como inadecuado

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BMC Musculoskeletal Disorders

, 11:274

First Online: 26 November 2010Received: 21 April 2010Accepted: 26 November 2010


BackgroundThere have been reports both supporting and refuting an inverse relationship between hip fracture and hip osteoarthritis OA. We explore this relationship using a case-control study design.

MethodsExclusion criteria were previous hip fracture same side or contralateral side, age younger than 60 years, foreign nationality, pathological fracture, rheumatoid arthritis and cases were radiographic examinations were not found in the archives. We studied all subjects with hip fracture that remained after the exclusion process that were treated at Akureyri University Hospital, Iceland 1990-2008, n = 562 74% women. Hip fracture cases were compared with a cohort of subjects with colon radiographs, n = 803 54% women to determine expected population prevalence of hip OA. Presence of radiographic hip OA was defined as a minimum joint space of 2.5 mm or less on an anteroposterior radiograph, or Kellgren and Lawrence grade 2 or higher. Possible causes of secondary osteoporosis were identified by review of medical records.

ResultsThe age-adjusted odds ratio OR for subjects with hip fracture having radiographic hip OA was 0.30 95% confidence interval 95% CI 0.12-0.74 for men and 0.33 95% CI 0.19-0.58 for women, compared to controls. The probability for subjects with hip fracture and hip OA having a secondary cause of osteoporosis was three times higher than for subjects with hip fracture without hip OA.

ConclusionThe results of our study support an inverse relationship between hip fractures and hip OA.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-11-274 contains supplementary material, which is available to authorized users.

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Autor: Jonas Franklin - Martin Englund - Torvaldur Ingvarsson - Stefan Lohmander


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