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Cardiovascular Diabetology

, 8:6

First Online: 30 January 2009Received: 19 December 2008Accepted: 30 January 2009

Abstract

BackgroundA high prevalence of impaired glucose tolerance and unknown type 2-diabetes in patients with coronary heart disease and no previous diagnosis of diabetes have been reported. The aims of the present study were to investigate the prevalence of abnormal glucose regulation AGR 3 months after an acute ST-elevation myocardial infarction STEMI in patients without known glucometabolic disturbance, to evaluate the reliability of a 75-g oral glucose tolerance test OGTT performed very early after an acute STEMI to predict the presence of AGR at 3 months, and to study other potential predictors measured in-hospital for AGR at 3 months.

MethodsThis was an observational cohort study prospectively enrolling 224 STEMI patients treated with primary PCI. An OGTT was performed very early after an acute STEMI and was repeated in 200 patients after 3 months. We summarised the exact agreement observed, and assessed the observed reproducibility of the OGTTs performed in-hospital and at follow up. The patients were classified into glucometabolic categories defined according to the World Health Organisation criteria. AGR was defined as the sum of impaired fasting glucose, impaired glucose tolerance and type 2-diabetes.

ResultsThe prevalence of AGR at three months was 24.9% 95% CI 19.1, 31.4%, reduced from 46.9% 95% CI 40.2, 53.6 when measured in-hospital. Only, 108 of 201 54% patients remained in the same glucometabolic category after a repeated OGTT. High levels of HbA1c and admission plasma glucose in-hospital significantly predicted AGR at 3 months p < 0.001, p = 0.040, respectively, and fasting plasma glucose was predictive when patients with large myocardial infarction were excluded p < 0.001.

ConclusionThe prevalence of AGR in STEMI patients was lower than expected. HbA1c, admission plasma glucose and fasting plasma glucose measured in-hospital seem to be useful as early markers of longstanding glucometabolic disturbance. An OGTT performed very early after a STEMI did not provide reliable information on long-term glucometabolic state and should probably not be recommended.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-8-6 contains supplementary material, which is available to authorized users.

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Autor: Eva C Knudsen - Ingebjørg Seljeflot - Michael Abdelnoor - Jan Eritsland - Arild Mangschau - Harald Arnesen - Geir Ø And

Fuente: https://link.springer.com/article/10.1186/1475-2840-8-6







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