Test-retest variability of quantitative 11CPIB studies in Alzheimer’s diseaseReportar como inadecuado




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European Journal of Nuclear Medicine and Molecular Imaging

, Volume 36, Issue 10, pp 1629–1638

First Online: 22 April 2009Received: 28 November 2008Accepted: 20 March 2009

Abstract

PurposeThe aim of this study was to assess the test-retest variability of CPIB studies in patients with Alzheimer’s disease AD and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.

MethodsCPIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.

ResultsTest-retest variability was best ∼3% for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ∼10% were found for plasma input models. Cerebellar VT values did not differ significantly between AD and controls.

ConclusionParametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of CPIB PET studies.

KeywordsPittsburgh compound B PIB Arterial sampling Cerebellum Parametric images Amyloid PET  Download fulltext PDF



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Fuente: https://link.springer.com/



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