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Arthritis Research and Therapy

, 13:R66

First Online: 18 April 2011Received: 02 December 2010Revised: 23 February 2011Accepted: 18 April 2011


IntroductionOur purpose was to test the hypothesis that hyperuricemia is associated with coronary artery calcification CAC among a relatively healthy population, and that the extent of calcification is directly proportional to the serum uric acid sUA concentration.

MethodsData from 2,498 participants in the Coronary Artery Risk Development in Young Adults CARDIA study were analyzed using logistic regression models. Subjects were free of clinical heart disease, diabetes, and renal impairment. The main measure was the presence of any CAC by computerized tomography Agatston score >0.

ResultsForty-eight percent of the study participants were male and 45% were African-American. Mean ± SD age was 40 ± 4 years, body mass index 28 ± 6 kg-m, Framingham risk score -0.7 ± 5%, blood pressure 113 ± 14-75 ± 11 mmHg, alcohol consumption 12 ± 27 ml-day, and sUA 297 ± 89 μmol-L 5.0 ± 1.5 mg-dL. Prevalence of CAC increased with sUA concentration among both men and women. Adjusted for age, gender, race, lipoproteins, triglycerides, smoking, blood pressure, presence of metabolic syndrome, C-reactive protein, waist circumference, alcohol use, creatinine, and serum albumin, the highest quartile of sUA >393 μmol-L 6.6 mg-dL for men and >274 μmol-L 4.6 mg-dL for women was associated with an odds ratio of 1.87 1.19-2.93 compared to the lowest quartile <291 μmol-L 4.9 mg-dL for men and <196 μmol-L 3.3 mg-dL for women. Among those with any CAC, each unit increase in sUA was associated with a 22% increase in Agatston score P = 0.008 after adjusting for the above covariates.

ConclusionsHyperuricemia is an independent risk factor for subclinical atherosclerosis in young adults.

AbbreviationsCACcoronary artery calcification

CADcoronary artery disease

CARDIACoronary Artery Risk Development in Young Adults

CIconfidence interval

CTcomputed tomography

EBCTelectron beam computerized tomography

OLSordinary least square

ORodds ratio

sUAserum uric acid

TCStotal coronary calcium score.

Electronic supplementary materialThe online version of this article doi:10.1186-ar3322 contains supplementary material, which is available to authorized users.

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Autor: Eswar Krishnan - Bhavik J Pandya - Lorinda Chung - Omar Dabbous

Fuente: https://link.springer.com/

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