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BMC Musculoskeletal Disorders

, 12:187

Clinical rheumatology and osteoporosis

Abstract

BackgroundOsteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD.

MethodsIn our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density BMD. Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures.

Results76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA densitometry measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly p = 0.01 with reduced BMD, whereas seven bone-specific laboratory values p = 0.046 correlated significantly.

ConclusionsAnamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-12-187 contains supplementary material, which is available to authorized users.

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Autor: Leila Kolios - Caner Takur - Arash Moghaddam - Mirjam Hitzler - Heinrich Schmidt-Gayk - Arnold J Suda - Bernd Höner - Pau

Fuente: https://link.springer.com/







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