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Journal of Cardiovascular Magnetic Resonance

, 12:20

First Online: 31 March 2010Received: 01 October 2009Accepted: 31 March 2010

Abstract

BackgroundAs myocardial oxygenation may serve as a marker for ischemia and microvascular dysfunction, it could be clinically useful to have a non-invasive measure of changes in myocardial oxygenation.
However, the impact of induced blood flow changes on oxygenation is not well understood.
We used oxygenation-sensitive CMR to assess the relations between myocardial oxygenation and coronary sinus blood oxygen saturation SvO2 and coronary blood flow in a dog model in which hyperemia was induced by intracoronary administration of vasodilators.

ResultsDuring administration of acetylcholine and adenosine, CMR signal intensity correlated linearly with simultaneously measured SvO2 r = 0.74, P < 0.001.
Both SvO2 and CMR signal intensity were exponentially related to coronary blood flow, with SvO2 approaching 87%.

ConclusionsMyocardial oxygenation as assessed with oxygenation-sensitive CMR imaging is linearly related to SvO2 and is exponentially related to vasodilator-induced increases of blood flow.
Oxygenation-sensitive CMR may be useful to assess ischemia and microvascular function in patients.
Its clinical utility should be evaluated.

AbbreviationsBOLDBlood-Oxygen-Level-Dependent

CMRCardiovascular Magnetic Resonance

FOVField of view

Fr or FFrench

GRE-EPIGRadient Echo-Echo Planar Imaging

LCXLeft circumflex coronary artery

MRIMagnetic resonance imaging

PxPixel

SSFPSteady-state-free-precession

SvO2Venous oxygen saturation

Electronic supplementary materialThe online version of this article doi:10.1186-1532-429X-12-20 contains supplementary material, which is available to authorized users.

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Fuente: https://link.springer.com/article/10.1186/1532-429X-12-20



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