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Arthritis Research and Therapy

, 14:R13

First Online: 18 January 2012Received: 29 July 2011Revised: 20 December 2011Accepted: 18 January 2012


IntroductionBone marrow lesions BMLs play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs.

MethodsIn total, 394 older men and women mean age, 63 years; range, 52 to 79 were measured at baseline and approximately 2.7 years later. BMLs were determined by using T2-weighted fat-saturation magnetic resonance imaging MRI by measuring the maximal area of the lesion. Nutrient intake total energy, fat, carbohydrate, protein, and sugar and serum lipids were assessed at baseline.

ResultsCross-sectionally, dietary factors and lipids were not significantly associated with BMLs. Energy, carbohydrate, and sugar intake but not fat were positively associated with a change in BML size β = 15.44 to 19.27 mm per 1 SD increase; all P < 0.05. High-density lipoprotein HDL cholesterol tended to be negatively associated with BML change β = -11.66 mm per 1 SD increase; P = 0.088.

ConclusionsEnergy, carbohydrate, and sugar intake may be risk factors for BML development and progression. HDL cholesterol seems protective against BMLs. These results suggest that macronutrients and lipids may be important in BML etiology and that dietary modification may alter BML natural history.


βbeta coefficient

BMIbody mass index

BMLsbone marrow lesions

CIconfidence interval

FFQfood-frequency questionnaire

HDLhigh-density lipoprotein

LDLlow-density lipoprotein

LSCleast significant criterion

MRImagnetic resonance imaging


ORodds ratio

ROAradiographic osteoarthritis

SDstandard deviation

TASOACTasmanian Older Adult Cohort Study.

Electronic supplementary materialThe online version of this article doi:10.1186-ar3689 contains supplementary material, which is available to authorized users.

Dawn Doré, Jonathon de Hoog contributed equally to this work.

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Autor: Dawn Doré - Jonathon de Hoog - Graham Giles - Changhai Ding - Flavia Cicuttini - Graeme Jones

Fuente: https://link.springer.com/

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