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Oxidative Medicine and Cellular Longevity - Volume 2014 2014, Article ID 673628, 8 pages -

Research ArticleDepartment of Biochemistry, Faculty of Medicine, The National University of Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Received 30 June 2014; Accepted 3 November 2014; Published 19 November 2014

Academic Editor: Ersin Fadillioglu

Copyright © 2014 Zulaikha Sahhugi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aging is characterized by progressive decline in physiological and body function due to increase in oxidative damage. Gelam honey has been accounted to have high phenolic and nonphenolic content to attenuate oxidative damage. This study was to determine the effect of local gelam honey on oxidative damage of aged rats. Twenty-four male Spraque-Dawley rats were divided into young 2 months and aged 19 months groups. Each group was further divided into control fed with plain water and supplemented with 2.5 mg-kg body weight of gelam honey for 8 months. DNA damage level was determined by comet assay and plasma malondialdehyde MDA by high performance liquid chromatography HPLC. The activity of blood and cardiac antioxidant enzymes was determined by spectrophotometer. The DNA damage and MDA level were reduced in both gelam honey supplemented groups. Gelam honey increases erythrocytes CAT and cardiac SOD activities in young and cardiac CAT activity in young and aged groups. The DNA damage was increased in the aged group compared to young group, but reduced at the end of the study. The decline of oxidative damage in rats supplemented with gelam honey might be through the modulation of antioxidant enzyme activities.

Autor: Zulaikha Sahhugi, Siti Maisarah Hasenan, and Zakiah Jubri



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