The effect of physical loading on calcaneus quantitative ultrasound measurement: a cross-section studyReport as inadecuate

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BMC Musculoskeletal Disorders

, 13:70

Clinical diagnostics and imaging


BackgroundPhysical loading leads to a deformation of bone microstructure and may influence quantitative ultrasound QUS parameters. This study aims at evaluating the effect of physical loading on bone QUS measurement, and further, on the potential of diagnosing osteoporosis using QUS method under physical loading condition.

Methods16 healthy young females control group and 45 postmenopausal women divided into 3 groups according to the years since menopause YSM were studied. QUS parameters were measured at calcaneus under self-weight loading standing and no loading sitting conditions. Weight-normalized QUS parameter QUS parameter measured under loading condition divided by the weight of the subject was proposed to evaluate the influence of loading. T-test, One-Way analysis of variance one way ANOVA and receiver operating characteristic ROC analysis were applied for analysis.

ResultsIn QUS parameters, mainly normalized broadband ultrasound attenuation nBUA, measured with loading significantly differed from those measured without loading p < 0.05. The relative changes of weight-normalized QUS parameters on postmenopausal women with respect to premenopausal women under loading condition were larger than those on traditional QUS parameters measured without loading. In ROC analysis, weight-normalized QUS parameters showed their stronger discriminatory ability for menopause.

ConclusionsPhysical loading substantially influenced bone QUS measurement mainly nBUA. Weight-normalized QUS parameters can discriminate menopause more effectively. By considering the high relationship between menopause and osteoporosis, an inference was drawn that adding physical loading during measurement may be a probable way to improve the QUS based osteoporosis diagnosis.

KeywordsQuantitative ultrasound Osteoporosis Physical loading Menopause Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-13-70 contains supplementary material, which is available to authorized users.

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Author: Cheng-Rui Liu - Hai-Jun Niu - Fang Pu - Ling Wang - Lian-Wen Sun - Yu-Bo Fan - De-Yu Li


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