Effect of Hochuekkito on Alveolar Macrophage Inflammatory Responses in Hyperglycemic MiceReportar como inadecuado




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Inflammation

, Volume 35, Issue 4, pp 1294–1301

First Online: 26 February 2012

Abstract

Diabetes mellitus reduces immunological activity and increases susceptibility to various infections. Hochuekkito TJ-41 has been reported to improve the weakened physical condition of various chronic diseases. BALB-c mice were divided into three groups; groups A and B were fed a standard diet, and group C, a TJ-41 diet. Two weeks after starting these diets, hyperglycemia was induced in groups B and C by injection with streptozotocin. Two weeks later, bronchoalveolar lavage was performed. Toll-like receptor TLR ligands TLR2: peptidoglycan, PGN; TLR4: lipopolysaccharide, LPS; TLR5: flagellin, FLG were used to stimulate alveolar macrophages AMs, and TNF-α production was measured. Under hyperglycemic conditions and PGN or FLG stimulation, TNF-α production from AMs was significantly reduced in group B compared with group A. However, treatment with TJ-41 group C significantly improved the impaired production of TNF-α. These results suggest that, under hyperglycemic conditions, TJ-41 can improve the inflammatory responses of AMs with stimulation of TLR ligands.

KEY WORDSalveolar macrophage Toll-like receptor diabetes mellitus streptozotocin inflammatory response  Download fulltext PDF



Autor: Masayuki Nakayama - Yukihiko Sugiyama - Hideaki Yamasawa - Manabu Soda - Naoko Mato - Tatsuya Hosono - Masashi Bando

Fuente: https://link.springer.com/



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