A Novel Mechanical Thrombectomy Device for Retrieval of Intravascular ThrombusReport as inadecuate




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CardioVascular and Interventional Radiology

, Volume 34, Issue 2, pp 383–390

First Online: 12 November 2010Received: 09 April 2010Accepted: 05 October 2010

Abstract

PurposeThrombotic and embolic vascular occlusion represents a leading cause of morbidity and mortality. Currently available thrombectomy devices have limitations, including difficulty removing organized thrombus and clot fragmentation with distal embolization. A novel mechanical thrombectomy device MTD, designed to remove both hard and soft thrombus without trauma to the blood vessel, was tested in preclinical porcine models evaluating efficacy, safety, and ease of use.

Materials and MethodsA total of 26 vessels in 14 pigs underwent mechanical thrombectomy with MTD. Thrombectomy was performed in nine superficial femoral arteries, eight subclavian arteries, five primary branches of the subclavian artery, lateral thoracic artery or the thyrocervical trunk, and four external carotids. Subacute organized fibrin-laden thrombus was injected into the arteries producing vascular occlusion. The MTD was then used for thrombectomy to restore patency and blood flow.

ResultsIntact thrombus was retrieved from 24 of 26 of the vessels with a single pass of the MTD, resulting in complete restoration of patency in 21 vessels and partial patency in 4 vessels. In 8 cases that used an early design, the embolic material fragmented during withdrawal from the access sheath. In 4 procedures that used an early design, the MTD failed to deploy fully and the embolus was not completely captured. No intraprocedural complications or vascular damage occurred.

ConclusionsThe present pilot studies demonstrate basic safety and efficacy of a novel MTD with design attributes suitable for retrieval of intact acute and organized chronic thrombus. The device has potential intracranial and peripheral utility.

KeywordsThrombectomy Device Clot Artery  Download fulltext PDF



Author: Wayne L. Monsky - Stephanos Finitsis - Dino De Cicco - John M. Brock - John Kucharczyk - Richard E. Latchaw

Source: https://link.springer.com/







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