Motion frozen 18F-FDG cardiac PETReport as inadecuate

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Journal of Nuclear Cardiology

, Volume 18, Issue 2, pp 259–266

First Online: 16 December 2010Received: 23 February 2010Accepted: 20 November 2010


BackgroundPET reconstruction incorporating spatially variant 3D Point Spread Function PSF improves contrast and image resolution. -Cardiac Motion Frozen- CMF processing eliminates the influence of cardiac motion in static summed images. We have evaluated the combined use of CMF- and PSF-based reconstruction for high-resolution cardiac PET.

MethodsStatic and 16-bin ECG-gated images of 20 patients referred for F-FDG myocardial viability scans were obtained on a Siemens Biograph-64. CMF was applied to the gated images reconstructed with PSF. Myocardium to blood contrast, maximum left ventricle LV counts to defect contrast, contrast-to-noise CNR and wall thickness with standard reconstruction 2D-AWOSEM, PSF, ED-gated PSF, and CMF-PSF were compared.

ResultsThe measured wall thickness was 18.9 ± 5.2 mm for 2D-AWOSEM, 16.6 ± 4.5 mm for PSF, and 13.8 ± 3.9 mm for CMF-PSF reconstructed images all P < .05. The CMF-PSF myocardium to blood and maximum LV counts to defect contrasts 5.7 ± 2.7, 10.0 ± 5.7 were higher than for 2D-AWOSEM 3.5 ± 1.4, 6.5 ± 3.1 and for PSF 3.9 ± 1.7, 7.7 ± 3.7 CMF vs all other, P < .05. The CNR for CMF-PSF 26.3 ± 17.5 was comparable to PSF 29.1 ± 18.3, but higher than for ED-gated dataset 13.7 ± 8.8, P < .05.

ConclusionCombined CMF-PSF reconstruction increased myocardium to blood contrast, maximum LV counts to defect contrast and maintained equivalent noise when compared to static summed 2D-AWOSEM and PSF reconstruction.

KeywordsMetabolism: PET cardiac motion frozen point spread function cardiac imaging  Download fulltext PDF

Author: Ludovic Le Meunier - Piotr J. Slomka - Damini Dey - Amit Ramesh - Louis E. J. Thomson - Sean W. Hayes - John D. Fried


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