Distribution of cerebral blood flow in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery stenosisReport as inadecuate




Distribution of cerebral blood flow in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery stenosis - Download this document for free, or read online. Document in PDF available to download.

European Radiology

, Volume 21, Issue 4, pp 875–881

First Online: 18 September 2010Received: 24 May 2010Revised: 01 August 2010Accepted: 17 August 2010

Abstract

ObjectiveTo investigate the influence of internal carotid artery ICA stenosis on the distribution of blood flow to the caudate nucleus, lentiform nucleus, and thalamus.

MethodsWe studied 18 healthy control subjects, 20 patients with a unilateral asymptomatic ICA stenosis, and 15 patients with a recently symptomatic unilateral ICA stenosis. The contribution of the ICAs and the basilar artery to the perfusion of the deep brain structures was assessed by perfusion territory selective arterial spin labeling ASL MRI. Differences were tested with a two-tailed Fishers’ exact test.

ResultsThe caudate nucleus was predominantly supplied with blood by the ipsilateral ICA in all groups. In 4 of the 15 27% the symptomatic patients, the caudate nucleus partially received blood from the contralateral ICA, compared to none of the 18 healthy control subjects p = 0.03. The lentiform nucleus and the thalamus were predominantly supplied with blood by the ipsilateral ICA and basilar artery respectively in all groups.

ConclusionIn patients with a symptomatic ICA stenosis, the caudate nucleus may be supplied with blood by the contralateral ICA more often than in healthy controls.

KeywordsMagnetic resonance imaging Cerebral hemodynamics Perfusion Basal ganglia Carotid artery stenosis  Download fulltext PDF



Author: Nolan S. Hartkamp - Reinoud P. H. Bokkers - H. Bart van der Worp - M. J. P. van Osch - L. Jaap Kappelle - Jeroen He

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