No red cell alloimmunization or change of clinical outcome after using fresh frozen cancellous allograft bone for acetabular reconstruction in revision hip arthroplasty: a follow up studyReport as inadecuate




No red cell alloimmunization or change of clinical outcome after using fresh frozen cancellous allograft bone for acetabular reconstruction in revision hip arthroplasty: a follow up study - Download this document for free, or read online. Document in PDF available to download.

BMC Musculoskeletal Disorders

, 13:187

Orthopedics and biomechanics

Abstract

BackgroundPossible immunization to blood group or other antigens and subsequent inhibition of remodeling or incorporation after use of untreated human bone allograft was described previously. This study presents the immunological, clinical and radiological results of 30 patients with acetabular revisions using fresh frozen non-irradiated bone allograft.

MethodsAB0-incompatible donor-recipient bone transplantation was performed in 22 cases, RhD incompatible transplantation in 6 cases. The mean follow up of 23 months included measuring Harris hip score and radiological examination with evaluation of remodeling of the bone graft, implant migration and heterotopic ossification. In addition, all patients were screened for alloimmunization to Rh blood group antigens.

ResultsCompared to the whole study group, there were no differences in clinical or radiological measurements for the groups with AB0- or RhD-incompatible bone transplantation. The mean Harris Hip Score was 80.6. X-rays confirmed total remodeling of all allografts with no acetabular loosening. At follow up, blood tests revealed no alloimmunization to Rh blood group donor antigens.

ConclusionsThe use of fresh frozen non-irradiated bone allograft in acetabular revision is a reliable supplement to reconstruction. The risk of alloimmunization to donor-blood group antigens after AB0- or Rh-incompatible allograft transplantation with a negative long-term influence on bone-remodeling or the clinical outcome is negligible.

KeywordsAcetabular revision Allograft bone Remodeling Alloimmunization AB0 Rhesus Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-13-187 contains supplementary material, which is available to authorized users.

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Author: Falk Mittag - Matthias Straub - Richard Schäfer - Torsten Kluba - Ingmar Ipach

Source: https://link.springer.com/







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