Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalenceReport as inadecuate




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Cardiovascular Diabetology

, 10:20

First Online: 28 February 2011Received: 25 November 2010Accepted: 28 February 2011

Abstract

BackgroundApolipoprotein B100 apoB is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and-or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation.

ObjectivesWe used the Discriminant Ratio DR methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-intersubject variation into account, and to derive an unbiased equivalence equation.

MethodsFasting total C, HDL-C, apoB and triglycerides were measured in 45 diabetic patients. The DR of the underlying between-subject standard deviation SD to the within-subject SD was calculated from duplicates. Correlation coefficients between pairs were adjusted to include an estimate of the underlying correlation.

ResultsMean values day 1 1SD were 143 36 mg-dl non-HDL-C and 98 24 mg-dl apoB. The DR-s of both parameters were similar 1.76 and 1.83 p = 0.83. Pearson-s product-moment correlation coefficient between tests was very high 0.94, reaching unity 1.00 after attenuation adjustment. The unbiased equation of equivalence relating apoB to non-HDL-C had a slope of 0.65 and an intercept of 6.3 mg-dl.

ConclusionsThe discrimination power of non-HDL-C is similar to that of apoB to rank diabetic patients according to atherogenic cholesterol and lipoprotein burden. Since true correlation between variables reached unity, non-HDL-C may provide not only a metabolic surrogate but also a candidate biometrical equivalent to apoB, as non-HDL-C calculation is readily available.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-20 contains supplementary material, which is available to authorized users.

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Author: Michel P Hermans - Frank M Sacks - Sylvie A Ahn - Michel F Rousseau

Source: https://link.springer.com/article/10.1186/1475-2840-10-20







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