Value of oral glucose tolerance test in the acute phase of myocardial infarctionReport as inadecuate




Value of oral glucose tolerance test in the acute phase of myocardial infarction - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:21

First Online: 11 March 2011Received: 11 January 2011Accepted: 11 March 2011

Abstract

BackgroundAlthough European guidelines advise oral glucose tolerance test OGTT in patients with acute myocardial infarction AMI before or shortly after hospital discharge, data supporting this recommendation are inconclusive. We aimed to analyze whether disturbances in glucose metabolism diagnosed before hospital discharge in AMI patients represents a latent pre-existing condition or rather temporary finding. Additionally, we planned to investigate the value of pre-selected glycemic control parameters as predictors of long-term glucometabolic state.

MethodsWe assessed admission glycemia, glycated hemoglobin, mean blood glucose concentration on days 1 and 2 in 200 patients with a first AMI but without overt disturbances of glucose metabolism. We also performed OGTT at discharge and 3 months after discharge.

ResultsThe prevalence of disturbances in glucose metabolism as assessed by OGTT at 3 months was significantly lower than at discharge 29% vs. 48%, p = 0.0001. Disturbances in glucose metabolism were not confirmed in 63% of patients with impaired glucose tolerance and in 36% of patients with diabetes mellitus diagnosed during the acute phase of AMI. Age >77 years, glucose ≥12.06 mmol-l at 120 minutes during OGTT before discharge and mean blood glucose level on day 2 >7.5 mmol-l were identified as independent predictors of disturbances in glucose metabolism at the 3-month follow-up.

ConclusionsDisturbances in glucose metabolism observed in patients with a first AMI are predominantly transient. Elderly age, high plasma glucose concentration at 120 minutes during OGTT at discharge and elevated mean blood glucose level on day 2 were associated with sustained disturbances in glucose metabolism.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-21 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Agata Bronisz - Marek Kozinski - Przemyslaw Magielski - Tomasz Fabiszak - Joanna Gierach - Iwona Swiatkiewicz - Adam Sukien

Source: https://link.springer.com/article/10.1186/1475-2840-10-21







Related documents