Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitisReport as inadecuate




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BMC Musculoskeletal Disorders

, 13:191

First Online: 02 October 2012Received: 17 February 2012Accepted: 26 September 2012

Abstract

BackgroundAnkylosing spondylitis AS is a chronic inflammatory disease of spine and sacroiliac joints; it is characterized by new bone formation, and the disease processes can be accompanied by osteoporosis. In the present study, we investigated changes in bone mineral density BMD and in the levels of various bone turnover-related biomarkers and cytokines in a cohort of AS patients, with regard to clinical parameters, disease activity, and treatment regimen.

Methods55 AS patients and 33 healthy controls included in the study. Spinal mobility was assessed by the Bath Ankylosing Spondylitis Metrology Index BASMI, and radiologic changes were scored by the Bath Ankylosing Spondylitis Radiologic Index BASRI. Patients were also evaluated with the Bath Ankylosing Spondylitis Functional Index BASFI and the Bath Ankylosing Spondylitis Disease Activity Index BASDAI. Bone mineral density BMD assessed by dual energy X-ray absorptiometry. Various biomarkers and cytokines of bone turnover including osteoprotegerin OPG, serum band 5 tartrate-resistant acid phosphatase TRAP-5, soluble receptor activator of nuclear factor kappa-B ligand sRANKL, secreted frizzled-related protein 1 sFRP-1, Dickkopf-related protein 1 DKK-1, and sclerostin were studied.

ResultsThe levels of TRAP-5, NTX, sRANKL, sclerostin, sFRP-1, DKK-1, and IFNγ, were similar between the patients and controls p > 0.05, while BMD of femoral neck, and OPG levels were significantly lower in AS patients p < 0.05. In a subgroup analysis, patients with active disease had significantly higher concentrations of OPG compared with the inactive group. Rest of the biomarkers and cytokines of bone turnover were similar between the active and inactive disease groups. Subgroup analysis of patients receiving anti-TNFα agents and conventional therapy revealed that OPG concentrations were significantly lower in the patients receiving biological drugs, while BAP and DKK-1 were significantly higher in the patients treated with conventional agents.

ConclusionsIn this cross-sectional study we showed that OPG levels were significantly lower in AS patients compared to healthy subjects. On the other hand, the levels of wingless Wnt signal pathway inhibitors seem not altered. Ectopic bone formation in AS may be related to dysfunction of these molecules at the cellular level.

KeywordsAnkylosing spondylitis Bone mineral density OPG RANKL DKK-1  Download fulltext PDF



Author: Ali Taylan - Ismail Sari - Baris Akinci - Safak Bilge - Didem Kozaci - Servet Akar - Ayfer Colak - Hulya Yalcin - Necati 

Source: https://link.springer.com/







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