The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in ManReport as inadecuate




The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man - Download this document for free, or read online. Document in PDF available to download.

Oxidative Medicine and Cellular Longevity - Volume 2015 2015, Article ID 979645, 10 pages -

Research ArticleLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3855 Holman Street, Houston, TX 77204, USA

Received 6 March 2015; Revised 27 May 2015; Accepted 3 June 2015

Academic Editor: Gareth Davison

Copyright © 2015 Austin B. Bigley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The redeployment of NK-cells in response to an acute bout of exercise is thought to be an integral component of the -fight-or-flight- response, preparing the body for potential injury or infection. We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the young. In the current study, we examined the effect of aging on the redeployment of NK-cells with exercise in the context of CMV. We show here that CMV blunts the exercise-induced redeployment of NK-cells in both younger 23–39 yrs and older 50–64 yrs subjects with older subjects showing the largest postexercise mobilization and 1 h postexercise egress of NK-cells. The blunted exercise response in individuals was associated with a decreased relative redeployment of the CD158a+ and CD57+ NK-cell subsets in younger and older individuals. In addition, we show that aging is associated with a CMV-independent increase in the proportion of NK-cells expressing the terminal differentiation marker CD57, while CMV is associated with an age-dependent decrease in the proportion of NK-cells expressing the inhibitory receptors KLRG1 in the younger group and CD158a in the older group. Collectively, these data suggest that CMV may decrease NK-cell mediated immunosurveillance after exercise in both younger and older individuals.





Author: Austin B. Bigley, Guillaume Spielmann, Nadia Agha, and Richard J. Simpson

Source: https://www.hindawi.com/



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