Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction - a cardiovascular magnetic resonance tagging studyReport as inadecuate




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Journal of Cardiovascular Magnetic Resonance

, 13:22

First Online: 17 March 2011Received: 17 November 2010Accepted: 17 March 2011

Abstract

BackgroundTrials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium. This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial ASTAMI explored global and regional myocardial function after intracoronary injection of autologous mononuclear bone marrow cells mBMC in acute anterior wall myocardial infarction treated with percutaneous coronary intervention.

MethodsCardiovascular magnetic resonance CMR tagging was performed 2-3 weeks and 6 months after revascularization in 15 patients treated with intracoronary stem cell injection mBMC group and in 13 controls without sham injection. Global and regional left ventricular LV strain and LV twist were correlated to cine CMR and late gadolinium enhancement LGE.

ResultsIn the control group myocardial function as measured by strain improved for the global LV 6 months: -13.1 ± 2.4 versus 2-3 weeks: -11.9 ± 3.4%, p = 0.014 and for the infarct zone -11.8 ± 3.0 versus -9.3 ± 4.1%, p = 0.001, and significantly more than in the mBMC group inter-group p = 0.027 for global strain, respectively p = 0.009 for infarct zone strain. LV infarct mass decreased 35.7 ± 20.4 versus 45.7 ± 29.5 g, p = 0.024, also significantly more pronounced than the mBMC group inter-group p = 0.034. LV twist was initially low and remained unchanged irrespective of therapy.

ConclusionsLGE and strain findings quite similarly demonstrate subtle differences between the mBMC and control groups. Intracoronary injection of autologous mBMC did not strengthen regional or global myocardial function in this substudy.

Trial registrationClinicalTrials.gov: NCT00199823

Electronic supplementary materialThe online version of this article doi:10.1186-1532-429X-13-22 contains supplementary material, which is available to authorized users.

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Author: Einar Hopp - Ketil Lunde - Svein Solheim - Svend Aakhus - Harald Arnesen - Kolbjørn Forfang - Thor Edvardsen - Hans-Jørge

Source: https://link.springer.com/article/10.1186/1532-429X-13-22







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