Assessment of coronary artery disease and calcified coronary plaque burden by computed tomography in patients with and without diabetes mellitusReport as inadecuate




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European Radiology

, Volume 21, Issue 5, pp 944–953

First Online: 10 November 2010Received: 26 February 2010Revised: 12 September 2010Accepted: 18 September 2010

Abstract

PurposeTo compare the coronary atherosclerotic burden in patients with and without type-2 diabetes using CT Coronary Angiography CTCA.

Methods and Materials147 diabetic mean age: 65 ± 10 years; male: 89 and 979 nondiabetic patients mean age: 61 ± 13 years; male: 567 without a history of coronary artery disease CAD underwent CTCA. The per-patient number of diseased coronary segments was determined and each diseased segment was classified as showing obstructive lesion luminal narrowing >50% or not. Coronary calcium scoring CCS was assessed too.

ResultsDiabetics showed a higher number of diseased segments 4.1 ± 4.2 vs. 2.1 ± 3.0; p < 0.0001; a higher rate of CCS > 400 p < 0.001, obstructive CAD 37% vs. 18% of patients; p < 0.0001, and fewer normal coronary arteries 20% vs. 42%; p < 0.0001, as compared to nondiabetics. The percentage of patients with obstructive CAD paralleled increasing CCS in both groups. Diabetics with CCS ≤ 10 had a higher prevalence of coronary plaque 39.6% vs. 24.5%, p = 0.003 and obstructive CAD 12.5% vs. 3.8%, p = 0.01. Among patients with CCS ≤ 10 all diabetics with obstructive CAD had a zero CCS and one patient was asymptomatic.

ConclusionsDiabetes was associated with higher coronary plaque burden. The present study demonstrates that the absence of coronary calcification does not exclude obstructive CAD especially in diabetics.

KeywordsDiabetes mellitus Coronary artery disease CT coronary angiography  Download fulltext PDF



Author: Erica Maffei - Sara Seitun - Koen Nieman - Chiara Martini - Andrea Igoren Guaricci - Carlo Tedeschi - Annick C. Weustink

Source: https://link.springer.com/







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