Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imagingReport as inadecuate




Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imaging - Download this document for free, or read online. Document in PDF available to download.

Arthritis Research and Therapy

, 14:R212

First Online: 05 October 2012Received: 07 May 2012Revised: 29 June 2012Accepted: 05 October 2012

Abstract

IntroductionWe aimed to explore the associations between knee osteoarthritis OA-related tissue abnormalities assessed by conventional radiography CR and by high-resolution 3.0 Tesla magnetic resonance imaging MRI, as well as biomechanical factors and findings from physical examination in patients with knee OA.

MethodsThis was an explorative cross-sectional study of 105 patients with knee OA. Index knees were imaged using CR and MRI. Multiple features from CR and MRI cartilage, osteophytes, bone marrow lesions, effusion and synovitis were related to biomechanical factors quadriceps and hamstrings muscle strength, proprioceptive accuracy and varus-valgus laxity and physical examination findings bony tenderness, crepitus, bony enlargement and palpable warmth, using multivariable regression analyses.

ResultsQuadriceps weakness was associated with cartilage integrity, effusion, synovitis all detected by MRI and CR-detected joint space narrowing. Knee joint laxity was associated with MRI-detected cartilage integrity, CR-detected joint space narrowing and osteophyte formation. Multiple tissue abnormalities including cartilage integrity, osteophytes and effusion, but only those detected by MRI, were found to be associated with physical examination findings such as crepitus.

ConclusionWe observed clinically relevant findings, including a significant association between quadriceps weakness and both effusion and synovitis, detected by MRI. Inflammation was detected in over one-third of the participants, emphasizing the inflammatory component of OA and a possible important role for anti-inflammatory therapies in knee OA. In general, OA-related tissue abnormalities of the knee, even those detected by MRI, were found to be discordant with biomechanical and physical examination features.

AbbreviationsBMLbone marrow lesions

CRconventional radiography

JSWjoint space width

LTFlateral tibiofemoral

MRImagnetic resonance imaging

MTFmedial tibiofemoral

NSAIDnonsteroidal anti-inflammatory drug

OAosteoarthritis

PFpatellafemoral.

Electronic supplementary materialThe online version of this article doi:10.1186-ar4050 contains supplementary material, which is available to authorized users.

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Author: Jesper Knoop - Joost Dekker - Jan-Paul Klein - Marike van der Leeden - Martin van der Esch - Dick Reiding - Ramon E Voorne

Source: https://link.springer.com/







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