Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West AfricaReport as inadecuate




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International Journal of Hypertension - Volume 2015 2015, Article ID 979631, 7 pages -

Research Article

Centre de Recherche Biomoléculaire Pietro Annigoni CERBA, BP 364, Ouagadougou 01, Burkina Faso

Laboratoire de Biologie et Génétique Moléculaires LABIOGENE, Université de Ouagadougou, BP 7021, Ouagadougou 03, Burkina Faso

Ecole Supérieure des Techniques Biologiques et Alimentaires ESTBA-UL, Université de Lomé, BP 1515, Togo

Service de Cardiologie, CHU-Yalgado Ouédraogo, BP 7022, Ouagadougou 03, Burkina Faso

Centre Médical Saint Camille CMSC, BP 444, Ouagadougou 09, Burkina Faso

Laboratoire de Biologie Moléculaire et Cellulaire LABMC, Université des Sciences et Techniques de Masuku USTM, BP 943, Franceville, Gabon

Received 7 May 2015; Accepted 8 July 2015

Academic Editor: Tomohiro Katsuya

Copyright © 2015 Daméhan Tchelougou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M-T and AT1R 1166A-C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I-D polymorphism between patients and controls DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp. were significantly different p < 10

. The genotype DD of ACE gene OR = 3.40, p < 0.0001, the increasing age OR = 3.83, p < 0.0001, obesity OR = 4.84, p < 0.0001, dyslipidemia OR = 3.43, p = 0.021, and alcohol intake OR = 2.76, p < 0.0001 were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients.





Author: Daméhan Tchelougou, Jonas K. Kologo, Simplice D. Karou, Valentin N. Yaméogo, Cyrille Bisseye, Florencia W. Djigma, Djeneba

Source: https://www.hindawi.com/



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