Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patientsReport as inadecuate




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Cardiovascular Ultrasound

, 9:9

First Online: 01 April 2011Received: 21 January 2011Accepted: 01 April 2011

Abstract

BackgroundHuman immunodeficiency virus HIV infection and antiretroviral treatment are associated with metabolic and cardiovascular complications that potentially increase the risk of atherosclerosis and cardiovascular disease in this population. Measurement of arterial wall thickness has been used as a surrogate of extent, severity and progression of atherosclerosis. A cross-sectional cohort study was performed to compare the validity of two non-invasive arterial measures: carotid intima-media thickness IMT, a parameter of atherosclerosis, and ophthalmic artery resistance index OARI, an index of occlusive carotid artery disease.

MethodsA total of 95 patients receiving highly active antiretroviral therapy HAART for more than 12 months were consecutively enrolled. IMT and OARI were measured by 7.5 MHz linear probe.

ResultsThere was a significant linear increase in IMT and OARI values as the grade of cardiovascular risk 0.70 and 0.69 for very low risk, 0.86 and 0.72 for low risk and 0.98 and 0.74 for medium-high risk, p < 0.001. A IMT > 0.83 and an OARI > 0.72 were the most discriminatory values for predicting a cardiovascular risk ≥ 10% sensibility 89.6% and 75.8%; sensitivity 70.5% and 68.4%; p < 0.001.

ConclusionsOur data indicate that OARI may have a potential as a new precocious marker of subclinical atherosclerosis in HIV-1-infected patients.

KeywordsHIV cardiovascular risk atherosclerosis intima-media thickness ophthalmic artery resistance index AbbreviationsIMTcarotid intima-media thickness

OARIophthalmic artery resistance index

HAARThighly active antiretroviral therapy

HIVhuman immunodeficiency virus

OAophthalmic artery

HDLhigh-density lipoprotein

SDstandard deviation

ANOVAanalysis of variance, ROC: receiver operating characteristic

NNRTIsNon-nucleoside reverse transcriptase inhibitors

PIProtease inhibitors

Electronic supplementary materialThe online version of this article doi:10.1186-1476-7120-9-9 contains supplementary material, which is available to authorized users.

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Author: Pierfrancesco Grima - Marcello Guido - Roberto Chiavaroli - Antonella De Donno - Mariangela Tana - Antonella Zizza

Source: https://link.springer.com/article/10.1186/1476-7120-9-9







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