A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individualsReport as inadecuate




A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:27

First Online: 06 April 2011Received: 22 January 2011Accepted: 06 April 2011

Abstract

BackgroundSeveral studies have shown that common variants in the MTNR1B gene were associated with fasting glucose level and type 2 diabetes. The purpose of this study was to examine whether tagging single nucleotide polymorphisms SNPs in the MTNR1B region were associated with type 2 diabetes and related traits in a Han Chinese population.

MethodsWe investigated the association of polymorphisms in the MTNR1B gene with type 2 diabetes by employing a case-control study design 1118 cases and 1161 controls. Three tagging SNPs rs10830963, rs3781637, and rs1562444 with R>0.8 and minor allele frequency>0.05 across the region of the MTNR1B gene were studied. Genotyping was performed by matrix-assisted laser desorption-ionization time-of-flight mass spectroscopy using a MassARRAY platform.

ResultsThe polymorphism rs3781637 was associated with type 2 diabetes adjusted for age, sex and body mass index BMI in the additive model and recessive model OR = 1.22, 95% CI 1.01-1.46, p = 0.038 and OR = 2.81, 95% CI 1.28-6.17, p = 0.01, respectively. In the non-diabetic controls, rs3781637 was nominally associated with plasma triglyceride, total cholesterol and low density lipoprotein cholesterol LDL-C levels in the recessive model p = 0.018, 0.008 and 0.038, respectively. After adjustment for multiple comparisons, the associations of rs3781637 with total cholesterol and LDL-C remained significant in the recessive model the empirical p = 0.024 and 0.045, respectively, but the association between rs3781637 and triglyceride became non-significant the empirical p = 0.095. The associations of rs10830963 and rs1562444 with type 2 diabetes and related traits were not significant in the additive, dominant and recessive models.

ConclusionsThe rs3781637 A-G polymorphism of the MTNR1B gene is associated with type 2 diabetes, plasma, total cholesterol and LDL-C levels in the Han Chinese population.

AbbreviationsSNPsingle nucleotide polymorphism

MAFminor allele frequency

LDlinkage disequilibrium

SEMstandard error of mean

BMIbody mass index

CIconfidence interval

ORodds ratio

HDL-Chigh density lipoprotein cholesterol

LDL-Clow density lipoprotein cholesterol

T2DMtype 2 diabetes

HWEHardy-Weinberg equilibrium

HOMA-βhomeostasis model assessment of βcell function

CADcoronary heart disease

UCP2uncoupling protein 2

PCOSpolycystic ovary syndrome

AISadolescent idiopathic scoliosis.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-27 contains supplementary material, which is available to authorized users.

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Author: Yan Ling - Xiaomu Li - Qian Gu - Hongyan Chen - Daru Lu - Xin Gao

Source: https://link.springer.com/article/10.1186/1475-2840-10-27







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