Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetesReport as inadecuate

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Cardiovascular Diabetology

, 10:30

First Online: 15 April 2011Received: 05 April 2011Accepted: 15 April 2011


BackgroundIncreased fasting plasma glucose FPG, which includes impaired fasting glucose IFG, impaired glucose tolerance IGT, and diabetes, is a risk factor for arterial stiffness. While IFG is widely accepted as a cardiovascular risk factor, recent studies have argued that subjects with high-normal glucose level were characterized by a high incidence of cardiovascular disease. The purpose of this study is to investigate the relationship between FPG and arterial stiffness in non-diabetic healthy subjects.

MethodsWe recruited 697 subjects who visited the health promotion center of a university hospital from May 2007 to August 2008. Age, sex, body mass index BMI, resting heart rate, smoking habits, alcohol intake, exercise, blood pressure, medical history, FPG, lipid profile, high sensitivity C-reactive protein hs-CRP, and Brachial-ankle pulse wave velocity ba-PWV were measured. We performed correlation and multiple linear regression analyses to divide the research subjects into quartiles: Q1n = 172, 65 mg-dL ≤FPG < 84 mg-dL; Q2n = 188, 84 mg-dL ≤FPG < 91 mg-dl; Q3n = 199, 91 mg-dL ≤FPG < 100 mg-dL; Q4n = 138, 100 mg-dL ≤FPG < 126 mg-dL.

ResultsFPG has an independent, positive association with ba-PWV in non-diabetic subjects after correcting for confounding variables, including age, sex, BMI, blood pressure, resting heart rate, hs-CRP, lipid profile, and behavioral habits. The mean ba-PWV of the high-normal glucose group Q3, 1384 cm-s was higher than that of the low-normal glucose group 1303 ± 196 cm-s vs.1328 ± 167 cm-s, P < 0.05. The mean ba-PWV value in the IFG group 1469 ± 220 cm-s was higher than that in the normoglycemic group P < 0.05, respectively.

ConclusionsAn increase in FPG, even within the normal range, was associated with aggravated arterial stiffness. Further research is needed to determine the glycemic target value for the prevention of arterial stiffness in clinical and public health settings.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-30 contains supplementary material, which is available to authorized users.

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Author: Jin Young Shin - Hye Ree Lee - Duk Chul Lee


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