Low serum amylase in association with metabolic syndrome and diabetes: A community-based studyReport as inadecuate




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Cardiovascular Diabetology

, 10:34

First Online: 17 April 2011Received: 14 February 2011Accepted: 17 April 2011

Abstract

BackgroundLow serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome MetS and diabetes.

Research Design and MethodsSerum amylase, cardiometabolic risk factors, MetS Adult Treatment Panel III criteria, and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently April 2009-March 2010 and 5 years ago.

ResultsClinical variables, except for age and estimated glomerular filtration rate eGFR, shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors odds ratio 95% CI, 2.07 1.39-3.07 and 2.76 1.49-5.11, respectively. In subjects who underwent checkups 5 years ago n = 571, lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction.

ConclusionsOur results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions.

Keywordsserum amylase exocrine impaired insulin action metabolic syndrome diabetes kidney function GFR Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-34 contains supplementary material, which is available to authorized users.

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Author: Kei Nakajima - Tohru Nemoto - Toshitaka Muneyuki - Masafumi Kakei - Hiroshi Fuchigami - Hiromi Munakata

Source: https://link.springer.com/article/10.1186/1475-2840-10-34







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