Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adultsReport as inadecuate

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Cardiovascular Diabetology

, 10:36

First Online: 28 April 2011Received: 10 January 2011Accepted: 28 April 2011


BackgroundLeptin is associated with cardiovascular disease CVD; however, few studies have assessed its relationship with metabolic syndrome, especially in an Asian population. Therefore, the aim of the present study was to assess leptin levels and evaluate its association with CVD and metabolic syndrome.

MethodsIn 2009, 957 subjects, who underwent a routine physical examination and choose leptin examination, were selected to participate. Participants 269 females and 688 males were stratified according to leptin level quartiles. Metabolic syndrome was defined by NCEP ATP III using waist circumference cutoffs modified for Asian populations, and CVD risk was determined using the Framingham Heart Study profile.

ResultsLeptin levels were correlated with CVD risk in men and women. With the exception of fasting plasma glucose, increased leptin levels were observed as factors associated with metabolic syndrome increased in both males and females. After adjusting for age, an association between leptin levels and metabolic syndrome was observed. After adjusting for age alone or with tobacco use, subjects in the highest leptin quartile had a higher risk of having metabolic syndrome than those in the lowest quartile OR = 6.14 and 2.94 for men and women, respectively. After further adjustment for BMI, metabolic syndrome risk remained significantly increased with increasing leptin quartiles in men. Finally, increased leptin levels were a predictor of metabolic syndrome in men and women.

ConclusionsSerum leptin levels are correlated with CVD risk and metabolic syndrome. Analysis of leptin as part of routine physical examinations may prove beneficial for early diagnosis of metabolic syndrome.

KeywordsTaiwan obesity metabolic syndrome AbbreviationsATP IIIAdult Treatment Panel

BMIBody mass index

CVDCardiovascular diseases

FBGFasting blood glucose

HDL-CHigh-density lipoprotein cholesterol

LDL-CLow-density lipoprotein cholesterol

OROdds ratio

ROCReceived operating curve

NPYNeuropeptide Y



Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-36 contains supplementary material, which is available to authorized users.

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Author: Wen-Cheng Li - Kuang-Yu Hsiao - I-Chuan Chen - Yu-Che Chang - Shih-Hao Wang - Kuan-Han Wu


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