In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imagingReport as inadecuate




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European Radiology

, Volume 21, Issue 6, pp 1127–1135

First Online: 30 March 2011Received: 16 August 2010Revised: 16 November 2010Accepted: 29 November 2010

Abstract

ObjectiveTo explore and to compare the magnitude and spatial pattern of in vivo femorotibial cartilage deformation in healthy and in osteoarthritic OA knees.

MethodsOne knee each in 30 women age: 55 ± 6 years; BMI: 28 ± 2.4 kg-m; 11 healthy and 19 with radiographic femorotibial OA was examined at 3Tesla using a coronal fat-suppressed gradient echo SPGR sequence. Regional and subregional femorotibial cartilage thickness was determined under unloaded and loaded conditions, with 50% body weight being applied to the knee in 20° knee flexion during imaging.

ResultsCartilage became significantly p < 0.05 thinner during loading in the medial tibia −2.7%, the weight-bearing medial femur −4.1% and in the lateral tibia −1.8%, but not in the lateral femur +0.1%. The magnitude of deformation in the medial tibia and femur tended to be greater in osteoarthritic knees than in healthy knees. The subregional pattern of cartilage deformation was similar for the different stages of radiographic OA.

ConclusionOsteoarthritic cartilage tended to display greater deformation upon loading than healthy cartilage, suggesting that knee OA affects the mechanical properties of cartilage. The pattern of in vivo deformation indicated that cartilage loss in OA progression is mechanically driven.

KeywordsMR imaging Articular cartilage Osteoarthritis Knee Quantitative evaluation  Download fulltext PDF



Author: Sebastian Cotofana - Felix Eckstein - Wolfgang Wirth - Richard B. Souza - Xiaojuan Li - Bradley Wyman - Marie-Pierre Helli

Source: https://link.springer.com/







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