Evaluation of radial distribution of cartilage degeneration and necessity of pre-contrast measurements using radial dGEMRIC in adults with acetabular dysplasiaReport as inadecuate




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BMC Musculoskeletal Disorders

, 13:212

Clinical diagnostics and imaging

Abstract

BackgroundThe purpose of the present study was to investigate the radial distribution patterns of cartilage degeneration in dysplastic hips at different stages of secondary osteoarthritis OA by using radial delayed gadolinium-enhanced magnetic resonance imaging of cartilage dGEMRIC, and to assess whether pre-contrast measurements are necessary.

MethodsThirty-five hips in 21 subjects mean age ± SD, 27.6 ± 10.8 years with acetabular dysplasia lateral CE angle < 25° were studied. Severity of OA was assessed on radiographs using Tönnis grading. Pre- T1pre and post-contrast T1 T1Gd values were measured at 7 sub-regions on radial reformatted slices acquired from a 3-dimensional 3D T1 mapping sequence using a 1.5 T MR scanner. Values of radial T1pre, T1Gd and ΔR1 1-T1Gd - 1-T1pre of subgroups with different severity of OA were compared to those of the subgroup without OA using nonparametric tests, and bivariate linear Pearson correlations between radial T1Gd and ΔR1 were analyzed for each subgroup.

ResultsCompared to the subgroup without OA, the subgroup with mild OA was observed with a significant decrease in T1Gd in the anterosuperior to superior sub-regions mean, 476 ~ 507 ms, p = 0.026 ~ 0.042 and a significant increase in ΔR1 in the anterosuperior to superoposterior and posterior sub-regions mean, 0.93 ~ 1.37 s, p = 0.012 ~ 0.042. The subgroup with moderate to severe OA was observed with a significant overall decrease in T1Gd mean, 404 ~ 452 ms, p = 0.001 ~ 0.020 and an increase in ΔR1 mean, 1.17 ~1.69 s, p = 0.001 ~ 0.020. High correlations were observed between radial T1Gd and ΔR1 for all subgroups r = −0.869 ~ −0.944, p < 0.001.

ConclusionsRadial dGEMRIC without pre-contrast measurements is useful for evaluating different patterns of cartilage degeneration in the entire hip joint of patients with hip dysplasia, particularly for those in early stages of secondary OA.

KeywordsAcetabular dysplasia Cartilage degeneration Radial magnetic resonance imaging dGEMRIC AbbreviationsOAOsteoarthritis

ADAcetabular dysplasia

MRIMagnetic resonance imaging

dGEMRICDelayed gadolinium-enhanced magnetic resonance imaging of cartilage

Gd-DTPAGadopentetate

GAGsGlycosaminoglycans

3D3-dimensional

FAIFemoroacetabular impingement

T1GdPost-contrast T1 relaxation time

T1prePre-contrast T1 relaxation time

ΔR1Difference between the relaxation rates

LCE angleLateral center-edge angle of Wiberg

WOMACWestern Ontario and McMaster Universities Osteoarthritis

aanterior

asanterosuperior

sasuperoanterior

ssuperior

spsuperoposterior

psposterosuperior

pposterior

ROIregion of interest

ICCIntra-class correlation

CIConfidence intervals.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-13-212 contains supplementary material, which is available to authorized users.

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Author: Li Xu - Yongbin Su - Karl-Philipp Kienle - Daichi Hayashi - Ali Guermazi - Jing Zhang - Yongming Dai - Xiaoguang Cheng

Source: https://link.springer.com/







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