Heart-Type Fatty Acid Binding Protein H-FABP: Relationship with arterial ıntima-media thickness and role as diagnostic marker for atherosclerosis in patients with ımpaired glucose metabolismReport as inadecuate




Heart-Type Fatty Acid Binding Protein H-FABP: Relationship with arterial ıntima-media thickness and role as diagnostic marker for atherosclerosis in patients with ımpaired glucose metabolism - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:37

First Online: 02 May 2011Received: 18 February 2011Accepted: 02 May 2011

Abstract

BackgroundHeart type fatty acid binding protein H-FABP has been closely associated with acute coronary syndrome, cardiac abnormalities, stroke, and obstructive sleep disorder in previous studies. The aim of this study was to evaluate and compare the serum H-FABP levels and carotid artery intima-media thickness CIMT between patients with prediabetes and control subjects.

Research design and methodsWe measured serum H-FABP levels in 58 prediabetic patients, 29 with impaired fasting glucose IFG and 29 with impaired glucose tolerance IGT and 28 age-, sex- and body mass index-matched control subjects using a sandwich enzyme-linked immunosorbent assay ELISA, and in order to measure CIMT, all participants underwent high-resolution B-mode ultrasonography.

ResultsSerum H-FABP levels were significantly elevated in pre-diabetic patients when compared with that of control subjects IFG: 32.5 ± 34.2 ng-dL, IGT: 45.4 ± 45.8 ng-dL, control: 16.8 ± 14.9 ng-dL; p = 0.011. The difference in means of H-FABP levels between patients with IGT or IFG and control subjects was significant p = 0.010 and p = 0.009, respectively. CIMT was higher in the pre-diabetic groups compared with the control group IFG: 0.6 ± 0.1, IGT: 0.6 ± 0.1, control: 0.5 ± 0.1; p < 0.001, and H-FABP level was positively correlated with CIMT p < 0.001, rho = 0.626.

ConclusionOur results indicate that patients with pre-diabetes are at increased risk for cardiovascular disease. In addition, serum H-FABP levels could represent a useful marker for myocardial performance in patients with IFG and IGT.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-37 contains supplementary material, which is available to authorized users.

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Author: Basak Karbek - Mustafa Özbek - Nujen Colak Bozkurt - Zeynep Ginis - Askın Güngünes - İlknur Öztürk Ünsal - Erman 

Source: https://link.springer.com/article/10.1186/1475-2840-10-37







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